References

Primary and review literature cited across MOTC.info. Each entry links to its DOI and PubMed record.

Last reviewed and updated:

  1. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

    Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, et al. Cell Metabolism. 2015;21(3):443-454.

    Evidence type: Preclinical (cell and mouse)

    DOI: 10.1016/j.cmet.2015.02.009·PubMed 25738459

  2. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress

    Kim KH, Son JM, Benayoun BA, Lee C. Cell Metabolism. 2018;28(3):516-524.e7.

    Evidence type: Preclinical (cell)

    DOI: 10.1016/j.cmet.2018.06.008·PubMed 29983246

  3. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

    Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, et al. Nature Communications. 2021;12:470.

    Evidence type: Human measurements and mouse studies

    DOI: 10.1038/s41467-020-20790-0·PubMed 33473109

  4. The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

    Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, Hirose N. Aging Cell. 2015;14(5):921-923.

    Evidence type: Human genetic association

    DOI: 10.1111/acel.12389·PubMed 26289118

  5. Humanin: a harbinger of mitochondrial-derived peptides?

    Lee C, Yen K, Cohen P. Trends in Endocrinology & Metabolism. 2013;24(5):222-228.

    Evidence type: Review

    DOI: 10.1016/j.tem.2013.01.005·PubMed 23402768

  6. Mitochondrial-derived peptides in energy metabolism

    Merry TL, Chan A, Woodhead JST, Reynolds JC, Kumagai H, Kim SJ, Lee C. American Journal of Physiology-Endocrinology and Metabolism. 2020;319(4):E659-E666.

    Evidence type: Review

    DOI: 10.1152/ajpendo.00249.2020·PubMed 32776825