MOTS-c Studies Database
Key MOTS-c publications, organized by evidence type. The first-listed observation is a summary, not a conclusion.
Last reviewed and updated:
Study table
| Study | Year | Evidence type | Question | Observation | Limitation | Source |
|---|---|---|---|---|---|---|
| The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance [1] | 2015 | Animal / cellular | Metabolic effects of MOTS-c in cells and mice | Reported effects on insulin sensitivity and diet-induced obesity in mice, with AMPK-associated signaling. | Mouse model; results not shown in people. | DOI · PubMed |
| The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress [2] | 2018 | Cellular | Where MOTS-c acts within the cell | Reported translocation to the nucleus under metabolic stress and effects on gene expression. | Cell-culture conditions; in-vivo relevance under study. | DOI · PubMed |
| MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis [3] | 2021 | Human + animal | MOTS-c and exercise / age-related decline | Reported MOTS-c levels changing with exercise in humans and effects on physical performance in mice. | Human data are measurements of endogenous MOTS-c; the intervention data are from mice. | DOI · PubMed |
| The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? [4] | 2015 | Human (genetic) | A MOTS-c gene variant and longevity | Reported a genetic variant association in a Japanese cohort. | Association only; cannot show cause. | DOI · PubMed |
| Mitochondrial-derived peptides in energy metabolism [6] | 2020 | Review | Mitochondrial-derived peptides in energy metabolism | Summarizes the field. | Secondary source. | DOI · PubMed |
Methodology
Entries are drawn from PubMed-indexed literature and summarized conservatively. This is a selected list, not an exhaustive one. See the editorial policy and the full bibliography. Search ClinicalTrials.gov for registered MOTS-c studies.